Lisa Marie Knight, 29, vanished from Ossineke, Michigan on June 8, 2012. She was last seen at her ex-husband Lloyd Frey’s residence and made a distressed phone call at about 10:30 p.m. asking a friend to pick her up; the friend could not. Frey told investigators she left his home sometime during the night while he slept. Lisa had no vehicle and her cell phone has not been used since that call.

The case began as a routine missing person report when a friend filed a report four days later after Lisa missed an appointment. Investigators later upgraded the case and now suspect foul play, saying they believe she is likely deceased. Frey has been identified as a person of interest; searches of his property, including with cadaver dogs and examination of freshly poured concrete, have not produced human remains. The Michigan State Police describe the investigation as active and say tips from across the country and abroad have so far yielded no breakthrough.

Lisa was a mother of four and her family says she would not voluntarily cut off contact with her children. Does anyone who knew Lisa or who was in the Ossineke area on June 8, 2012 have information that could help the ongoing investigation?