A dispute over money at a Biloxi motel escalated into multiple killings on April 27, 2022. Mohammad Moeini, 51, owner of the Broadway Inn Express, was shot and killed at his business on the Mississippi Gulf Coast. Born in Iran, he had lived in Gulfport for 25 years and was described as a hardworking businessman, a devoted family man, and a well-regarded local poker player.

Two employees at the motel were also killed in the initial shooting: 61-year-old property manager Laura Lehman and 55-year-old maintenance worker Chad Green. Witnesses described a chaotic scene as gunfire erupted; the gunman was identified as 32-year-old Jeremy Alesunder Reynolds. After fleeing the motel, Reynolds carjacked and fatally shot 52-year-old public works employee William Waltman in nearby Gulfport, then barricaded himself inside a convenience store. Law enforcement entered the store and found Reynolds deceased; authorities later said he died from smoke inhalation after setting a fire during the standoff.