Karema Melendrez, 31, disappeared from Buffalo, New York, in the summer of 2019. She was last seen on July 25, 2019. At the time she was described as White/Caucasian, with black hair and brown eyes, 5 feet 3 inches tall and about 100 pounds. She was reportedly wearing a gray hoodie, gray pants and black sandals, and had a tattoo on her arm.

Her case was entered into the National Missing and Unidentified Persons System on June 25, 2020. The Buffalo Police Department is listed as the investigating agency under case number 19-208-0605. Public details list the location where she was last seen as unknown, and the timeline and circumstances leading to her disappearance are not provided, which has hampered the inquiry.

Anyone who knew Karema, saw her around July 25, 2019, or has information about her whereabouts is asked to contact the Buffalo Police Department.