Barbara Nellie Lunsford was 23 when she vanished from Lexington, Kentucky on October 12, 1963. She left her home near Short Street and Georgetown Street intending to take a local bus to a follow-up appointment at the University of Kentucky Medical Center after fainting at work about a week earlier; she had a history of seizures. She was married to Marion Lunsford and had three children. Barbara was last seen wearing a brown checked dress and was described as 5 feet 4 inches, about 115 pounds, with brown hair, blue eyes and an overbite.

A search in the Lexington area was reportedly conducted on January 17, 1964, but few details about that effort are available. The case went cold and remained unsolved for decades. In October 2020 the case was entered into the National Missing and Unidentified Persons System, reportedly at the request of a niece; by then her husband and two children had already died. There is little public information about what happened after her disappearance.

If anyone knew Barbara, lived in that neighborhood in 1963, or has information about her movements on October 12, 1963, please come forward.