Anne Elizabeth Matthews disappeared from Guelph, Ontario, after walking away from the Homewood Health Centre at 150 Delhi Street on December 8, 1983. She was a patient at the facility and was last seen stepping out into cold winter weather wearing a red felt coat with black embroidery along the bottom and a hood trimmed with fox fur, a light-colored turtleneck sweater, dark pants, and beige boots.

At the time she went missing Anne had black hair, hazel eyes, a fair complexion, a medium build, stood about 5 feet 7 inches and weighed roughly 126 pounds. The Guelph Police Service conducted a ground search of the area and pursued other leads but were unable to locate her. Her case remains open with Guelph Police under case number GU83026109.

Anyone who knew Anne, saw her that day, or has information about her movements after she left the facility is asked to contact the Guelph Police Service.