Roxanne Marie Isadore, a 25-year-old Indigenous woman from the Driftpile Cree Nation, was last definitively seen on June 20, 2008, in the area of 118 Avenue in Edmonton, Alberta. She was described as 5 feet 0 inches to 5 feet 1 inch, slender, 110–121 pounds, with long brown hair sometimes dyed red, brown eyes, false front teeth, a scar on her left shoulder, an appendix scar, a cross tattoo on her right middle finger and a large knife with a snake and heart tattoo on her right shin. She used several aliases, including Sunshine Courtoreille and Roxanne Blue.

Roxanne had moved to Edmonton from Valleyview in 2006 and was a mother of three children who were left in the care of their great-grandmother. Her family reports a history of domestic abuse and subsequent struggles with drug and alcohol dependency. The last contact with her sister was in September 2007; no regular calls came after that. Her family filed a missing person report with the Valleyview RCMP on September 24, 2013, and the investigation was later transferred to the Edmonton Police Service. Accessing health records proved difficult because her federal Health Canada records are maintained separately from provincial files.

Police and family have appealed to the public for information but no significant leads have emerged and the case remains open. If anyone knew Roxanne, her aliases, movements around Edmonton in 2007–2008, or has information about what happened to her, please come forward.