Desiree Serpas, 28, was found dead in a downtown Phoenix hotel room in the early morning hours of July 5, 2024. A hotel security guard discovered her at about 3:30 a.m. at the Renaissance Hotel near Central Avenue and Adams Street; she had suffered a gunshot wound to her back and was pronounced dead at the scene after fire department responders arrived.

Surveillance and witness accounts place Desiree and her ex-partner, 40-year-old Dominique Jackson, returning to the hotel around 11:30 p.m. after Fourth of July events. Hours later police were called for an unrelated disturbance: Jackson was located in the hotel lobby naked and making statements about demons. Jackson was the registered guest of the room where Desiree was found. Investigators reported finding a gun registered to Jackson and his clothing in the room, both with gunshot residue. The couple had prior family court involvement in 2020 and 2021 regarding a parenting plan for their two children.

Anyone with information about Desiree, her movements that night, or who saw the couple in downtown Phoenix on July 4–5 is asked to come forward.