Lillian Mae Mathis was 26 when she left Winston-Salem, North Carolina, for Columbia, South Carolina, in March 2010 and was never heard from again. She is described as a white female, blonde hair, blue eyes, 5 feet 4 inches, about 116 pounds, with a smiley face emblem burned into her right bicep. Friends and family called her Lilly and she sometimes used the name Lilly Spears.

The last confirmed sighting was in Columbia; an unconfirmed sighting in Winston-Salem was reported in November 2010. Beyond those movements, what happened after she arrived in Columbia is unclear, and the Winston-Salem Police Department lists the case as an active missing person investigation. Only limited, fragmented details are available, which has made reconstructing her timeline difficult.

If anyone knew Lillian, saw her in Columbia or Winston-Salem in 2010, or has information that could clarify her movements, please come forward.