Luis Enrique Villa Rubio was 20 when he and his brother Jose Villa Rubio were last seen in Modesto, California, on April 14, 2010. The brothers had come from Culiacán, Mexico, to look for work and disappeared together; neither has been heard from since. Luis was described as a Hispanic male, brown hair, hazel eyes, 5 feet 7 inches, about 200 pounds, wearing a black long-sleeved sweater, black pants and black shoes at the time he was last seen.

Investigators have said the disappearances may be linked to a local drug cartel and that both men were believed to have been murdered. In 2014 a property on Tuolumne Road connected to suspect Francisco Felix was searched but turned up no evidence related to the brothers. Felix was later sentenced in 2018 to twenty years for drug trafficking, but no charges have been filed in the Villa Rubio cases and the investigation remains an unsolved missing persons case handled by the Modesto Police Department.

If anyone knew Luis or Jose, their movements in Modesto in April 2010, or has information about the Tuolumne Road property, please share what is known.