Natalie Irene Fisher, known as Nat, was 21 when her body was found near the 400 block of Holmes Road in Houston on September 22, 2016. Officers arrived about 1:15 p.m. and discovered she had suffered multiple stab wounds; she was pronounced dead at the scene and formally identified on September 26, 2016.

Natalie was born September 15, 1995, in Andrews, Texas, and raised around Temple. Family remembered her for writing, music, makeup and her devotion to two young daughters, Olivia and Savannah. Her family believed she had been drawn into a human trafficking network that moved her between Dallas, Mississippi and Houston, and alleged she had been exploited at the Plainfield Inn near Bissonnet and Beltway 8 between 2015 and September 2016. The motel later faced a civil lawsuit from Natalie's mother claiming the operators knowingly permitted trafficking and related crimes; that litigation sought damages and did not name a murderer.

Houston police said on September 26, 2016, that there were no known witnesses or suspects; homicide detectives R. Klementich and T. Colbert handled the case. Who attacked Natalie and why remains unanswered — can anyone who knew her or saw activity near Holmes Road on September 22, 2016, come forward with information?