On the night of October 22, 2005, police in Portland, Oregon, responded to a stabbing at an apartment on Southwest 26th Avenue and found 33-year-old Hispanic male Ismael Santos Santos dead in a back bedroom with multiple stab wounds. The case was opened as Portland Police Bureau case 05-103193 and investigators treated it as a homicide.

No suspects were publicly identified and no arrests were made. The investigation went cold enough that the file was later transferred to the Cold Case Homicide Unit. Over the years authorities have periodically asked the public for information and Crime Stoppers of Oregon has offered a cash reward for tips that could lead to an arrest.

Whoever knew Ismael or was in that neighborhood that night may have information that could finally move this case forward; anyone with tips is asked to come forward.