Kaye Francis Reid Hamilton, 36, was last seen near her home in the Jenkins Road area of U.S. Highway 17 in Yemassee, South Carolina, on November 9, 1994. Her car was left at the residence and there were no signs of a struggle at the home. Family did not report her missing until several days later.

Investigators found that Kaye had been taking prescription medication that was never refilled after she vanished. The inquiry also noted she knew people involved in narcotics trafficking who suspected she was an informant, but authorities determined she was not and found no evidence linking those individuals to her disappearance. Forensic evidence at her home suggested foul play, and there has been no activity on her bank account since she disappeared.

Hundreds of deputies and volunteers searched the surrounding area with tracking dogs, helicopters, and all-terrain vehicles, but Kaye has not been found. She is described as a Black female, 5 feet 1 inch to 5 feet 3 inches, 115 to 140 pounds, with black hair, brown eyes, and a three-inch scar on her right hip. Her DNA is in the National Missing Persons DNA database for comparison.

If anyone knew Kaye, her movements around November 9, 1994, or has information that could help investigators, please come forward.