Renee Lynette Kyles went missing from Kalamazoo, Michigan, after being last seen on September 8, 2007. She was 53 by birth records (sometimes listed as 54), stood about five feet two inches to five feet three inches, weighed about 115 pounds, had brown eyes and black hair, and was often seen wearing a short black wig. Family described her as a mother and grandmother who had moved to Kalamazoo from Chicago in 1999 and who had been diagnosed with bipolar disorder but was not taking medication at the time she vanished.

A family member last saw her at a residence on Southworth Terrace; neighborhood witnesses reported seeing her get into a black Pontiac Vibe that afternoon. There was also an unconfirmed later sighting placing her in a large SUV that may have been a Nissan Pathfinder. Her family reported her missing on September 17 after she failed to contact her children or grandchildren and showed no financial activity.

On September 19 her Toyota Camry was found abandoned in the 1900 block of Portage Street with a broken window and clothing and a suitcase in the trunk.

Did anyone in Kalamazoo remember seeing Renee, the black Pontiac Vibe, or a large SUV around Southworth Terrace on September 8, 2007?