Cynthia Quarles was 34 when she disappeared from Buffalo, New York, on February 17, 1999. The last known contact was a telephone call she placed to a relative; the location she called from is unknown. No confirmed sightings or movements have been recorded after that call.

At the time she went missing Cynthia was described as an African American woman, 5 feet 7 inches tall, about 140 pounds, with brown hair that had been straightened from its natural braided style. Distinguishing features include two moles on her cheek about an inch apart, a mole on her forehead, a scar on her nose, and two piercings in her left ear. She may have been wearing blue jeans and a blue and beige flannel shirt when last seen, though that detail is uncertain.

The Buffalo Police Department has investigated the disappearance and the case is entered into national missing-person databases, including NamUs. No significant leads have been reported and the case remains open. If anyone knew Cynthia, saw her around February 17, 1999, or has information about where she might have been calling from, please come forward.