Lisa Ann Myers Neugent was 22 when she disappeared after leaving her parents’ home in Rockingham County, North Carolina, with her boyfriend Frank Lloyd Isley Jr.. The pair had been living in Conway, South Carolina; Lisa had moved there to be with Isley after leaving an abusive marriage and worked as a courier and later for his family business.

During a Labor Day visit with her parents in late summer 1999 the relationship frayed. After returning to her parents’ house, Lisa left with Isley to talk and was taken to the Sea Mist Resort in Cherry Grove Beach, South Carolina. She made calls that night — to a friend and then to her mother — and promised to return after a home repair project. She was never heard from again.

Investigators later found the Conway house ransacked; Isley had reportedly moved out weeks earlier. Authorities say a cut in the floor that looked like a doorway was found in the home during a later search, but no human remains were recovered. Isley was arrested months later on unrelated charges and ultimately gave no information about Lisa. Searches of the property continued into 2025 with no resolution.

Did anyone who knew Lisa in Conway or Cherry Grove Beach see her or Isley around that Labor Day weekend?