Karen Ann Brown was 42 when she vanished from St. Louis, Missouri, in the spring of 2009. She was last seen on May 28, 2009, at the Delmar Lounge wearing a long-sleeved tan shirt and blue jeans and may have been wearing a wig. Karen is Black, with black hair, brown eyes, about 5 feet 4 inches and 140 pounds. Her family reported her missing the same day and the St. Louis Metropolitan Police Department opened an investigation.

Karen lived with schizophrenia, a detail her family has highlighted as increasing her vulnerability. Public details about the evening she disappeared are sparse, and the investigation remains open with no widely reported leads. Her case is listed in national missing persons databases and has remained unresolved.

If anyone knew Karen, saw her the night of May 28, 2009, or has information about her whereabouts, please share what you remember.