Melanie Quadros was 27 when she was last seen in Lowell, Massachusetts, on January 18, 2010. She disappeared while walking her small brown Pomeranian, Rusty, near Bridge Street after making plans to meet someone that day; neither Melanie nor the dog were seen again. Her mother reported her missing a week later.

Melanie struggled with addiction and had a criminal record, including a warrant related to car theft, but remained close with family and friends. Her mother believes foul play is likely; the case has produced few solid leads.

Anyone with information should contact the Lowell Police Department.