John Joshua Isome, 35, was found gravely wounded inside a vehicle the night of August 5, 2025, near Mohawk Place and West McMicken Avenue in Cincinnati’s Over-the-Rhine. Responding officers reported gunshot wounds to his head and chest; a firearm was recovered in the car but investigators did not immediately say whether it had been used. He was taken to a hospital and later died.

Detectives say Isome picked up another man and that the passenger opened fire from inside the vehicle before fleeing on foot. Police described the suspect as wearing black but released no name and announced no arrests. Friends and relatives established memorial pages and an obituary identifying Isome and sharing photographs as the community cataloged the loss.

Anyone who was in Over-the-Rhine around Mohawk Place and West McMicken Avenue the night of August 5, or who has information about the passenger who fled, is asked to come forward.