Andre Lee Jeffery Sr., 46, was fatally shot while driving in Humboldt Park on the afternoon of May 24, 2025. Police say the single gunshot struck his head around 4:10 p.m. as he was behind the wheel in the 800 block of North Sacramento Avenue. His vehicle continued forward, striking a parked car and a light pole before stopping; he was taken to Mount Sinai Hospital in critical condition and pronounced dead at 10:30 p.m.

An autopsy conducted the next day listed a gunshot wound to the head as the cause of death and the manner as homicide. Area 1 detectives opened the investigation; initial reports and subsequent compendiums of media and official updates list no arrests and no suspect information in the immediate aftermath. Authorities describe the crash after the shooting as part of the incident scene.

Anyone with information about the shooting or who was in the 800 block of North Sacramento Avenue around 4:10 p.m. on May 24 is asked to come forward.