Brenda Sue Lefler was 31 when she was last seen in Greenacres, Florida, on May 2, 1974. She left a note saying she was running away with her boyfriend, but critical items were left behind: her purse, credit cards, and insulin needed to manage her diabetes. Those omissions made investigators suspect she may not have left willingly.

Brenda was described as 5 feet 7 inches, about 130 pounds, with red hair and hazel eyes. She wore prescription glasses and had arthritis that caused a curvature of her right index finger. Authorities have said a possible love triangle might have been involved, but despite ongoing interest and family hope for answers, no significant clues have emerged and the case remains unsolved.

Anyone who knew Brenda, her relationships, or who has information about Greenacres in May 1974 is asked to come forward.