On the evening of March 10, 2011, 24-year-old Sergio Lopez was shot and killed while visiting relatives in a northeast Las Vegas neighborhood. The shooting occurred at about 7:15 p.m. in the 5600 block of Lake Mead Boulevard near Nellis Boulevard after Lopez was confronted by an armed individual. The shooter fled eastbound on Lake Mead Boulevard immediately after the shooting. Emergency services responded but Lopez succumbed to his wound.

Police opened a homicide investigation but did not determine a motive in the immediate aftermath, and no arrests were made in the days following the killing. The case later grew cold and remains unsolved; the suspect or suspects have not been publicly identified or apprehended. If anyone has information about that March 10 encounter or the person who fled east on Lake Mead Boulevard, please come forward.