Jacquelyn Lorraine Jackie Markham, 51, was last seen in Callahan, Florida on December 14, 2000. She stopped at an Eckerd pharmacy just before 7:00 p.m. to pick up blood‑pressure medication and was due to meet her boyfriend that evening. He reports she called to say a male acquaintance, Richard, had come to the home intoxicated and she asked him not to come over; when the boyfriend arrived both Jackie and the man were gone. Her car, prescription, dog, fish and other personal items remained in the house, and there were no signs of forced entry or struggle.

Her purse was later found in a ditch in Jacksonville about 15 miles away with credit cards and ID still inside. Investigators developed multiple leads over the years, including a nearby registered sex offender who later denied involvement and died in custody; detectives said his involvement seemed unlikely. Surveillance released in late 2022 shows a red‑haired man holding a missing‑person flyer who may have information. No body has been recovered and no arrests have been announced.

If anyone knew Jackie, her routines, or saw anything on the night of December 14, 2000, contact the Nassau County Sheriff’s Office.