Cathy Anne Smith was 26 when she vanished from Kansas City, Missouri. She was last seen July 1, 1981, while traveling from Kansas City to Harrison, Georgia, where she intended to relocate. Cathy sometimes used the names Kathy Anne Smith, Kathy Anne Parker, or Cathy Anne Parker and worked for the Frisco Railroad, later acquired by the Burlington Railroad.

Described as a white female with brown shoulder-length hair, blue eyes, height between 5 feet 10 inches and 6 feet 3 inches, and weighing 160 to 180 pounds, Cathy never reached her destination and has not been heard from since. Very few details about her movements or contacts that day are available, and the Kansas City Police Department lists the investigation as open.

Does anyone who traveled between Kansas City and Harrison, Georgia, in 1981 or who knew Cathy then have information that could help explain what happened after she left town?