On October 25, 2021, 18-year-old Junior Alfredo Santiago was shot and killed in Knoxville, Tennessee. Santiago, who was Hispanic, was found inside an overturned vehicle on Cansler Avenue near Wallace Street in the Mechanicsville neighborhood. He had been shot at least once and was pronounced dead at the scene.

Two suspects approached; one, a 15-year-old, fired and struck Santiago in the side of the face. Santiago reportedly attempted to drive away while returning fire, but his car crashed and he succumbed to his injuries. A 15-year-old was arrested the next day and charged with a juvenile petition for possession of a weapon with intent to go armed. A second 15-year-old was later charged with first-degree murder, and prosecutors sought to transfer that juvenile to adult court.

The case was handled amid a broader effort by Knoxville police to address a string of teen shooting deaths in the area. If anyone knew Santiago, his movements that day, or has information that could help investigators, please come forward.