Kareem Lee Brandon, a 21-year-old Black man from Johnstown, Pennsylvania, was shot on the night of February 1, 2017, in the Moxham neighborhood. The shooting occurred around 9:30 p.m. on the sidewalk in the 400 block of Grove Avenue. He was taken to Conemaugh Memorial Medical Center and pronounced dead at 10:16 p.m.; the Cambria County coroner ruled the death a homicide from multiple gunshot wounds.

In the immediate aftermath police said there was no clear motive and no identified suspects. Officers interviewed two people and later released surveillance video showing a man on a bicycle and two other men near the scene; those two men were described as acting suspiciously but were not identified as suspects. Through 2017 the case remained open with no arrest.

Years later detectives said they had a strong idea who killed Brandon and why but lacked cooperative eyewitness testimony to file charges. Investigators have reexamined the file and continued to ask anyone who saw something on February 1, 2017, to come forward to provide the missing piece that could move the case to charges.