Reny Jose, a 21-year-old Rice University senior, disappeared on March 3, 2014, while on a Spring Break trip to Panama City Beach, Florida. He and 22 other students rented a beach house on Front Beach Road; Reny was last seen there about 7:00 p.m. that evening. The next morning friends reported him missing after finding some of his clothing and personal items, including his phone, in a trash bin near the house. His wallet, laptop, and other belongings remained in his bedroom.

Authorities have suggested Reny may have drowned while under the influence of drugs, based on friends who said he had taken LSD and voiced suicidal thoughts. His family disputes that account, saying Reny was a top student with no history of drug use or suicidal tendencies and expressing concern about possible foul play. Extensive searches and investigations have not produced definitive evidence, and the case remains unsolved.

Anyone who was in Panama City Beach that night or who knew Reny and might shed light on his movements is asked to come forward.