Manuel Lopez Jr., a 17-year-old Hispanic student, was shot and killed on September 5, 2018, in Cleveland, Ohio. He and his 19-year-old sister, Giselle Lopez, were killed outside their Garfield Heights home after Manuel intervened during a heated argument between their mother and her live-in boyfriend, Matthew Nicholson. Reports say Nicholson fired at the siblings as they tried to flee.

Nicholson, described as 29 and working as a private security officer at the time, was arrested and charged with two counts of murder and three counts of domestic violence. The deaths devastated the Garfield Heights community; Manuel had just begun his senior year at Garfield Heights High School and was known for his dedication to his studies, while Giselle had graduated with honors and was taking classes at Cuyahoga Community College with plans to become a nurse. Their father, Manuel Lopez Sr., publicly expressed grief and disbelief over the loss.