On March 31, 2010, 25-year-old Monica Muse was killed in a triple homicide in the Treme neighborhood of New Orleans. She and two other women found dead at the scene were identified as her sister Jennifer Muse and their mother Wanda Wagner Simpson. The three women were discovered inside a residence, having succumbed to fatal injuries.

The New Orleans Police Department launched an extensive investigation. A suspect was later identified and taken into custody, and legal proceedings were started in connection with the killings. The family reported deep sorrow; an obituary describes Monica as a beloved daughter, sister, and granddaughter.