Isabel Santana was 17 when she vanished from Nashville, Tennessee. She was last seen March 24, 2007. At the time she was described as a White/Hispanic female with black hair and brown eyes, between 5 feet 0 inches and 5 feet 4 inches tall and weighing 125 to 130 pounds.

Isabel was an immigrant living in a group home when she disappeared and her case is classified as endangered missing. There are few concrete details about her last movements; nothing definitive is reported about what she was wearing or how she left. Her disappearance has raised concerns that she may have been a victim of human trafficking. Her case is being handled by the Metropolitan Nashville Police Department and is listed in NamUs as MP34797; the National Center for Missing & Exploited Children is also involved.

If anyone knew Isabel, lived near the group home, or has information about her whereabouts in March 2007, please share what you know.