Karla Lopez-Santos was 23 when she was last seen on September 1, 2015. She is described as Hispanic and Caucasian, with black hair, brown eyes, standing between 5 feet 0 inches and 5 feet 2 inches tall, and weighing about 115 to 120 pounds. The last known sighting was near an Albertsons grocery store in Battleground, Washington, but the Gresham Police Department in Oregon is handling the investigation and lists Portland as a last known location.

A report was filed with Gresham on March 2, 2016, and the case was entered into NamUs on March 3, 2016. Public details about what led to her being reported missing are sparse, and the investigation remains open. If anyone saw Karla around Battleground or Portland in late summer 2015, or has any information that could help, please contact the Gresham Police Department.