Guadalupe Ortiz-Santiago was 17 when she went missing from San Luis Obispo, California, on October 9, 2005. She is listed as a missing person by the California Department of Justice; the case remains open.

Guadalupe is described as Hispanic/Latino. Specifics such as height, weight, or the clothing she was last seen wearing have not been made widely available. Authorities encourage anyone with information to contact the San Luis Obispo Police Department or statewide hotlines to assist the ongoing investigation.