Brenda Sue Murdock was 47 when she was last known to have contact in the Williston, North Dakota area around November 2015. NamUs lists her last contact as November 1, 2015, and identifies the Williston Police Department as the investigating agency. She is described as a White female, 5 feet 6 inches, about 160 pounds, with blond or strawberry-blond hair and brown eyes. She has also been known as Brenda Romero and may have used the last name Rodriguez.

Before she disappeared Brenda worked in the Williston area at hotels, a gas station, and a grocery store. Accounts say she sometimes traveled or wandered but normally stayed in touch with her mother, making the months of silence after November 2015 unusual. She was not reported missing until February 21, 2016.

On February 24, 2016 two women in Rapid City, South Dakota reported giving a ride to a hitchhiker who resembled Brenda and said she was headed to North Dakota for a job; investigators obtained footage but it was not clear enough to confirm identity. Brenda had ties to Colorado, where her twin sister lived, but there is no confirmed contact with family there after November 2015. Her whereabouts remain unknown; anyone with information is asked to contact the Williston Police Department.