On the evening of February 6, 2021, 33-year-old Lorenzo Sanchez Hunter was shot in the chest on B Street in Anderson, South Carolina. He was taken to a local hospital and died the next day, February 7. Another victim in the same incident, 24-year-old Daquavious Antonio Tillison, was pronounced dead at the scene from a gunshot wound to the head.

Anderson police identified three suspects in the double homicide: 39-year-old Frank Thomas Rhoads, 31-year-old William Christopher Flynn, and 19-year-old Dominick Michael Rhoads. Warrants were issued charging each man with two counts of murder, and authorities warned they were armed and dangerous and might be traveling in either a black Ford Fusion or a gray Chevrolet Suburban.

A multi-state manhunt ended in Virginia on February 12, 2021, when Virginia troopers tried to stop the Fusion on Interstate 81. The car fled, drove the wrong way in northbound lanes, crashed into a tree and the three occupants ran; they were captured nearby. Frank Rhoads was treated for minor injuries and also faced Virginia charges including eluding, reckless driving, and altered plates. Did anyone in Anderson or along I-81 see the Fusion or the Suburban around February 6–12, 2021?