On the evening of February 20, 2021, Shirley Ann Rivera Isaac, 43, was fatally shot in the neck inside a residence on Resort Street in Santee, South Carolina. The house was occupied at the time by six adults and five children; a child also suffered a gunshot wound to the arm. Emergency responders attended, and the Orangeburg County Coroner’s Office confirmed Shirley’s death.

The Orangeburg County Sheriff’s Office opened a homicide investigation after two vehicles at the home were found damaged during the incident. An obituary described Shirley as a wife, mother of six and grandmother, mourned by a large extended family and community. Despite multiple people being in the home when the shooting occurred, no arrests or publicly identified suspects had been announced as of late 2025 and investigators described the case as unresolved.

Did anyone in Santee know Shirley or see anything on Resort Street that night that might help the investigation?