On the afternoon of November 21, 2018, Brandon Knighten, 27, was found unconscious and not breathing inside a vehicle in the 1500 block of Locust Street in Downtown West, Saint Louis. First responders arrived around 3:25 p.m.; Knighten was transported to a nearby hospital but died of his injuries. Evidence was scattered across the street at the daylight scene.

Four other people were in the vehicle when the shooting occurred: a 37-year-old man and three children, ages 4, 5 and 7. Authorities confirmed none of those passengers were injured. The Homicide Division took over the investigation, and in the days after the shooting police had not identified a suspect or released a description of a shooter. Anyone with information is asked to contact CrimeStoppers.