Jacqueline Santana was 16 when she disappeared from her Philadelphia home in the winter of 2019. The last known contact with Jacqueline was on February 4, 2019. She is described as Hispanic, with brown hair and brown eyes, standing about 5 feet 5 inches to 5 feet 7 inches and weighing between 115 and 125 pounds.

Authorities say the circumstances suggested she ran away and that she was suspected to be with a boyfriend, possibly in the Germantown area of Philadelphia. The Philadelphia Police Department filed a report three days after her last contact and her case was entered into the National Missing and Unidentified Persons System in September 2019. Clothing and distinctive physical features have not been publicly detailed.

Anyone who knew Jacqueline, her circle, or who may have seen a teenage Hispanic girl matching this description in Germantown around early February 2019 is asked to come forward with information.